Subsequently, we extracted the SNP data of HCC cases from the TCGA-LIHC cohort and found that the rs121913396, rs121913400, rs121913407 SNP of CTNNB1, and rs28934571 SNP of TP53 gene were relatively high frequency (Additional file 10: Fig. S9a). The gene discussed is CTNNB1; the disease is hepatocellular carcinoma.