To explore whether the protein and/or mRNA expression of ets1 and KMT5A in DN participants and rats was consistent with the protein and/or mRNA expression of ets1 and KMT5A of the in vitro study, ets1 and KMT5A levels were assessed in kidney tissues and/or aortic tissues of DN patients and rats. The gene discussed is ETS1; the disease is liver dysplastic nodule.