The resulting functional annotation showed that the methylated aberration of lncRNAs can perturb tumor-related signal pathways, containing the regulation of transcription, cell differentiation, protein kinase activation, nucleotide binding, cellular target components, RAS/RAF/MEK/MAPK, and PI3K/Akt /mTOR signaling pathways [18]. The gene discussed is AKT1; the disease is neoplasm.