The stratification analysis by quality of study revealed that IL8RB rs1126579 C > T polymorphism was associated with elevated cancer risk in high-quality studies (homozygous model: 95% CI = 1.01–1.28, P = 0.028, recessive model: 95% CI = 1.16–1.27, P = 0.002). This evidence concerns the gene CXCR2 and cancer.