The COVID-19 lead variant rs74956615T>A in TYK2, which confers risk for critical illness (OR (95% CI) = 1.43 (1.29–1.59), P = 9.71 × 10−12) and hospitalization due to COVID-19 (OR (95% CI) = 1.27 (1.18–1.36), P = 5.05 × 10−10) is correlated with the missense variant rs34536443:G>C (p.Pro1104Ala; r2 = 0.82). The gene discussed is TYK2; the disease is COVID-19.