CXCL10 and myocardial infarction: Furthermore, some SASP components are known to be beneficial to recovery following IR clinically, for example, increased expression of the cytokine IP-10, which was reduced by senescence elimination in preclinical models (Dookun et al., 2020b), at 15 min post-IR correlates with higher systolic function at 12-weeks post-IR in patients, indicating that expression of IP-10 in the acute phase following MI confers cardioprotection (Shmeleva et al., 2015).