We found that transfection of poly I:C (a dsRNA mimic) or infection with the R296T mutant induced the formation of G3BP1-positive/TIA1-negative RNase L-dependent bodies (RLBs) in WT cells and PKR KO cells, whereas infection with the K287T mutant induced RLBs in PKR KO cells (S10 Fig). The gene discussed is EIF2AK2; the disease is infection.