We found that transfection of poly I:C (a dsRNA mimic) or infection with the R296T mutant induced the formation of G3BP1-positive/TIA1-negative RNase L-dependent bodies (RLBs) in WT cells and PKR KO cells, whereas infection with the K287T mutant induced RLBs in PKR KO cells (S10 Fig). This evidence concerns the gene TIA1 and infection.