These pathways also include genes such as Tnfaip3 (A20), which is implicated in T cell activation and activation induced cell death, and Tob1, a negative regulator of T cell activation, suggesting that Hulk-expanded 2W1S-specific CD4+ T cells may be intrinsically negatively regulated to a greater extent than those expanded during 2W-Salmonella infection [40,41]. The gene discussed is CD4; the disease is Salmonella Infections.