A role of MT1-MMP in resistance to genotoxic stresses has been observed also in glioblastoma multiforme, where MT1-MMP depletion sensitizes to radiation and temozolomide [40]; and in MT1-MMP knock-out mouse fibroblasts, where lack of MT1-MMP causes premature senescence and accumulation of DNA damage [41]. This evidence concerns the gene MMP14 and glioblastoma.