ELANE and cancer: Similar to Park and colleagues, we also found that PDA4 and NE activity are important for pancreatic cancer cell–induced NET formation and NET-mediated cancer cell invasion; however, we found that NADPH inhibition had no effect on NET-mediated tumor cell invasion, suggesting that PDAC cells induce NET formation and NET-mediated PATC cell invasion through an NADPH oxidase–independent pathway (Supplemental Figure 3, B and C, and Figure 5D).