Taken together, we conclude that collagen stimulates pancreatic cancer cells to produce CXCL5 through a DDR1/PKCθ/SYK/NF-κB pathway, and as a result, CXCL5 induces TANs to form NETs and promote cancer cell invasion and metastasis. The gene discussed is CXCL5; the disease is pancreatic neoplasm.