BCL11B and autism: Heterotopias were characterized by the presence of TBR1 and CTIP2 (postmitotic neuroblasts) and TBR2 (IP) positive cells (Figure 7C), a phenotype typically attributed to defects in radial migration of cortical projection neurons in models of autism or related heterotopias (24), as well as the presence of cells with abnormal nuclear morphologies, multilobulated nuclei, or abnormally large nuclei, suggestive of previous aberrations during chromosome segregation (Figure 7D).