AGFG1 and diabetes mellitus: The abnormal activitiesof GGTase-II and some Rab proteins havebeen identified in several diseases, including cancer, such as pancreas,breast, skin, colon, lung, ovarian, and prostate, to name just a few.277 GGTase-II alone was not reported to be up-or downregulated in diabetes, but some Rab GTPases can be associatedwith various aspects of T2D (Table 3).