INS and hyperinsulinism: Most prenylated proteins belongto the Ras-related G proteins, particularly Ras, Rab, and Rho thatcontrol cell growth, differentiation, proliferation, biomolecule synthesis,and membrane trafficking.6 Of interestin this regard, hyperinsulinemia was shown to upregulate prenyltransferases,7 and selective inhibitors of prenylation markedlyincreased insulin sensitivity.8,9 Moreover, sustainedinflammation-induced prenylation of Rho GTPase mediated inhibitionof insulin-promoted glucose uptake, causing fasting hyperglycemia.10