However, although statins werereported to improve insulin resistance and reduce systemic inflammation,some studies have shown that statins might have increased the incidenceof diabetes.11 Farnesyl diphosphate synthase(FPPS) and geranylgeranyl diphosphate synthase (GGPPS), downstreamof HMG-CoA reductase, catalyze the production of FPP and GGPP, respectively.Bisphosphonates (BPs), the inhibitors of FPPS, constitute one of themain classes of drugs used to treat bone-associated diseases. This evidence concerns the gene FDPS and diabetes mellitus.