Importantly,any changes in muscle properties in the muscle-specific Ggpps knockout mice were not observed, suggesting that a deficit of GGPPalone probably does not affect muscle morphology and performance.124 Therefore, GGPPS in skeletal muscle and adiposetissue may be a potential pharmacological target for the prophylaxisof insulin resistance and T2D treatment. Here, GGPS1 is linked to Insulin resistance.