INS and type 2 diabetes mellitus: In retrospectivecohort studies, the exposure to BPs (alendronate, risedronate) wasassociated with reduced T2D incidence.12 Moreover, the administration of BPs was shown to positively affectdiabetes-related indices, insulin, fasting plasma glucose (FPG), andhemoglobin A1c (HbA1c).13 On the otherhand, overexpression of muscle,14 adipose,15 and liver16 GGPPSmay contribute to insulin resistance pathogenesis.