One of the most studied PTMs is protein prenylation,which is crucial for glucose-stimulated insulin secretion (GSIS) bypancreatic β-cells.17 However, severalproteins within the mevalonate pathway may be implicated in T2D development.Here, we discuss the mechanisms of small GTPase prenylation and howinhibition of various points in the mevalonate pathway might affectprotein prenylation and functioning of pancreas and liver, skeletalmuscle, kidneys, adipose tissue, and contribute to chronic inflammationinvolved in T2D development. This evidence concerns the gene INS and type 2 diabetes mellitus.