In retrospectivecohort studies, the exposure to BPs (alendronate, risedronate) wasassociated with reduced T2D incidence.12 Moreover, the administration of BPs was shown to positively affectdiabetes-related indices, insulin, fasting plasma glucose (FPG), andhemoglobin A1c (HbA1c).13 On the otherhand, overexpression of muscle,14 adipose,15 and liver16 GGPPSmay contribute to insulin resistance pathogenesis. This evidence concerns the gene INS and Insulin resistance.