Despite the low sequence identitybetween human FFPS and GGPPS (17%), their tertiary (but not quaternary)structures are surprisingly similar and their catalytic mechanismsare probably similar.207 Therefore, manyattempts at obtaining GGPPS inhibitors led to the development of dualFPPS and GGPPS inhibitors, such as compound 8 (Figure 7), which is about100 times more potent than zoledronic acid in obstructing tumor growth,222 or compound 7, which representsanother chemotype of GGPPS bisphosphonate inhibitors and shows ∼15×higher activity toward GGPPS, compared with FPPS.223. The gene discussed is GGPS1; the disease is neoplasm.