CAE is more common in human immunodeficiency virus (HIV) infection [13], and is associated with higher levels of uric acid, high-sensitivity C-reactive protein (hs-CRP) [14], and other inflammatory cytokines such as interleukin-1b, tumor necrosis factor alpha (TNF-α), and interleukin 10 [15]. This evidence concerns the gene MAP3K14 and HIV infectious disease.