In our study aiming to reveal the relationship between MDA and SOD levels, which are used for evaluating the oxidative stress status of the organism in CAD patients as well as the RhoA/ROCK-1 signal pathway, it was observed that RhoA, ROCK-1, and MDA levels of the CAD group increased compared to the control group, and SOD levels decreased. This evidence concerns the gene ROCK1 and coronary artery disorder.