Neurological changes related to CPB time have been widely studied and its complications are well-established in clinical practice, where many pathophysiologic changes take place, including coagulation disorders and activation of the inflammatory cascade caused by mechanical stress to the elements involved in changed blood flow, triggering release of cytokines such as tumour necrosis factor alpha, interleukin (IL)-6, and IL-8 [23,24]. Here, IL6 is linked to blood coagulation disease.