One reason could be the decreased presence of myeloid‐derived suppressor cells (MDSCs).[36] Previous studies suggest that tumor‐derived CCL2 recruits CCR2+ MDSCs, which in turn impedes the infiltration of CD8+ T cells.[37] Our flow cytometry analysis supports this mechanism, suggesting that over time, intermittent aerosolized delivery of let‐7b reduces the number of suppressive myeloid cells (G‐MDSCs) as well as Tregs within tumors. Here, CCL2 is linked to neoplasm.