Immune checkpoint inhibitors (ICI) (anti-CTLA-4, anti-PD-1, anti-PD-L1) may constitute a breakthrough in terms of a new type of immunotherapy in the treatment of cancer as they have contributed to improvement in the prognosis of patients with neoplasms, such as melanoma, non-small cell lung cancer (NSCLC), urothelial carcinoma, renal cell carcinoma, head and neck squamous cell cancer (HNSCC), or neoplasms of the lymphatic system—Hodgkin’s lymphoma. This evidence concerns the gene CD274 and renal cell carcinoma.