The inhibitory activity of LY294002 reduced LN229 (glioblastoma) and U251 (astrocytoma) cells proliferation and invasiveness in vitro and impacted the expression of multiple survival pathways like PI3K-Akt/PKB-mTOR (Jane et al. 2006). The gene discussed is AKT1; the disease is astrocytoma (excluding glioblastoma).