LRP5 and osteoporosis: Another study evaluating the impact of two common LRP5 single nucleotide polymorphisms (rs4988300 and rs634008) on bone turnover markers in a cohort of 328 unrelated osteoporosis patients with or without fractures, found that the bone formation marker PINP levels and BMD were lower in patients with the GG genotype of rs4988300 and the TT genotype of rs634008 than in patients with the other genotypes [51].