Because MYC has been reported to repress anti-tumor immune responses in tumors, including in Kras-driven lung and pancreatic adenocarcinomas (Casey et al., 2016; Kortlever et al., 2017; Muthalagu et al., 2020), MGA may normally act to limit MYC repression of these genes. Here, MGA is linked to pancreatic adenocarcinoma.