OCLN and infectious disease: TIV increased carbohydrate metabolism (14.50 ± 3.00 × 10−3 or 14.60 ± 2.00 × 10−3 or 14.90 ± 2.00 × 10−3 vs.13.80 ± 4.00 × 10−3%), replication and repair functions (5.60 ± 1.00 × 10−3 or 5.60 ± 1.00 × 10−3 vs. 5.10 ± 4.00 × 10−3%), reduced the frequency of infectious disease (1.60 ± 2.00 × 10−4 or 1.90 ± 5.00 × 10−4 or 1.80 ± 3.00 × 10−4 vs. 2.20 ± 7.00 × 10−3%), BBB permeability (0.77 ± 0.30 vs. 1.81 ± 0.33 μg/g), and up-regulated the expression of ZO-1 (1.42-fold, 1.60-fold, 1.71-fold) and occludin (1.79-fold, 2.20-fold).