Focusing on FRα, it is a membrane glycoprotein that is overexpressed on the surface of various tumor types, including NSCLC as well as pancreatic, ovarian, and breast cancers (Hartmann et al., 2007; Iwakiri et al., 2008; Kalli et al., 2008), whereas it is expressed at a low level on the apical surface of normal epithelial cells of the lungs, kidneys, choroid plexus, and uterus (Fernández et al., 2018). The gene discussed is FOLR1; the disease is neoplasm.