In a study by Phan et al., (2020) attenuated S. typhimurium was used to deliver an shRNA plasmid against IDO (shIDO-ST) in two CRC murine models and was shown to effectively decrease the level of IDO and mitigate tumour growth in immunocompetent CRC mouse models compared with a scrambled shRNA control and a clinically relevant IDO inhibitor [126]. The gene discussed is IDO1; the disease is neoplasm.