TNFSF10 and colorectal carcinoma: Multiple groups have successfully incorporated various plasmids of cDNA for human soluble tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) into an attenuated strain of Lactococcus lactis to secrete biologically active TRAIL, which have proved to induce apoptosis in multiple human CRC cell lines including HCT116 and SW480 [133,134].