This finding is further supported by the observation that the treatment of iron-loaded FthΔ/Δ mice, with a pharmacological NF-κB blocker BAY11-7082 (31) concomitantly with Salmonella infection, could neither reduce systemic cytokine production (Supplemental Figure 9A) nor improve infection control (Supplemental Figure 9B) and worsened the pathological phenotype. Here, NFKB1 is linked to infection.