NFKB1 and Salmonella Infections: This finding is further supported by the observation that the treatment of iron-loaded FthΔ/Δ mice, with a pharmacological NF-κB blocker BAY11-7082 (31) concomitantly with Salmonella infection, could neither reduce systemic cytokine production (Supplemental Figure 9A) nor improve infection control (Supplemental Figure 9B) and worsened the pathological phenotype.