However, even though some level of hypersensitivity of the NF-κB signaling pathway upon iron loading and myeloid FTH deficiency could be observed, it is unlikely that this mechanism solely underlies the dramatically increased cytokine response and mortality in iron-loaded FthΔ/Δ mice upon bacterial infection. The gene discussed is FTH1; the disease is hyperinsulinemic hypoglycemia, familial, 4.