This analysis revealed a prominent overrepresentation of binding sites of various NF-κB isoforms (NF-κB, NFKB1, REL, and RELA) both in promoters of the downregulated and upregulated gene set, indicating that the aberrant iron turnover in iron-loaded FthΔ/Δ animals upon infection massively interferes with the NF-κB signaling pathway (Figure 3, E and F). Here, NFKB1 is linked to infection.