Consistent with JunD as a key effector of JNK, JunD levels were increased in correlation with the increased tumor burden in c-Junfl/fl; lsl-Jnkk2-Jnk1; lsl-K-RasG12D lungs, with positive staining for phospho-JunD Ser100 (Figure 4E). This evidence concerns the gene JUND and neoplasm.