The average tumor grade was also increased, with c-Junfl/fl; lsl-K-RasG12D animals exhibiting grade 4 LADCs, which were HMGA2+/TTF-1– and not observed in controls (Supplemental Figure 1, C and D), and some additionally showing lepidic predominant adenocarcinoma (formerly BAC) lesions (Supplemental Figure 1E). Here, HMGA2 is linked to minimally invasive lung adenocarcinoma.