HepG2 has a large in-frame deletion in the CTNNB1 gene comprising 116 codons of exons 3 and 4 (Koch et al. 1999) and a mutation of the TERT promoter (Cevik et al. 2015) and represents the fetal tumor subtype with high GLUL expression and GS abundance (Lopez-Terrada et al. 2009b). The gene discussed is TERT; the disease is neoplasm.