As expected, B-cell depleted lymphoma patients had lower B-cell scores as compared to controls (see Supplemental Figure 4B, http://links.lww.com/HS/A169), showing significant and large fold lower expression of B-cell genes, including MS4A1 (CD20), CD19, CD79A, and FCRL2 (Fig. 4B). Here, MS4A1 is linked to lymphoma.