VWF and von Willebrand disease (hereditary or acquired): The disease is known to be heterogeneous in genotype and phenotype.1Type 1 is the most common variant, accounting for 70 to 80% of cases, followed by type 2, which affects approximately 20% of patients and is subclassified into four major subtypes.1Type 3, the most severe form of VWD, is characterized by a near-complete absence of VWF, and affects <5% of VWD patients.1