Interestingly, both of the 2 groups of genes targeted by upregulated miRNAs or downregulated miRNAs were enriched in the process, prostate cancer, pathways in cancer, HTLV-I infection, hepatitis B, p53 signaling pathway, pancreatic cancer, cell cycle, and chronic myeloid leukemia. The gene discussed is TP53; the disease is familial pancreatic carcinoma.