Since there is no study to examine the relationship between liver enzymes and cardiometabolic diseases (MetS, HTN, and CVD) in the Kurdish population of Iran, this cross-sectional population-based study was conducted to assess the relationship between liver enzymes (ALT, AST, ALT/AST ratio, GGT, and ALP) and MetS, HTN, and CVD. This evidence concerns the gene GPT and hypertensive disorder.