Platelet activation as measured by release markers during an acute ischemic stroke (AIS) has been demonstrated in many studies, showing elevated plasma levels of sP-selectin (131–138), sCD40L (134), sGPVI (139), and sCLEC2 (140, 141) in comparison to healthy volunteers (Table 4, Supplementary Table 1). Here, CD40LG is linked to androgen insensitivity syndrome.