Finally, several transcription factors have been implicated in HXKII regulation in a variety of cancers, like hypoxia inducible factor 1α (HIF-1α) (Ma et al., 2021), the signal transducer and activator of transcription 3 (STAT3) and p53 (Rodríguez-Enríquez et al.,). Here, STAT3 is linked to cancer.