It has also been shown that inhibition of GSK-3 down-regulates the expression of MMP-2 and MT1-MMP in glioblastoma cells and that MMP-2 activation is mediated by the interaction of its pro-form with another metalloprotease, MT1-MMP, and TIMP-2 (Hernandez-Barrantes et al., 2000; Chikano et al., 2015). Here, TIMP2 is linked to glioblastoma.