By analyzing PD-L1 expression in a large cohort of HCC patients, Kurebayashi et al. (2018) and others showed that PD-L1 expression in tumor infiltrates is associated with the progenitor subtype of HCC, marked by CK19 and SALL4 expression (Calderaro et al., 2016). Here, CD274 is linked to hepatocellular carcinoma.