IFNG and lung carcinoma: In lung cancer, tumor-derived mesenchymal stem cells (MSCs) alter the NK cell phenotype by downregulating activating receptor expression and inhibiting interferon gamma (IFN-γ) secretion, whereas abortion of PGE2 and restoration of IL-6 activity reverse the tumor-derived MSC-mediated immunosuppression activities (Galland et al., 2017).