Paradoxically, Pfn1 also shows anti-tumor and anti-metastatic activities for various types of cancer (breast, pancreatic, and liver) (Janke et al., 2000; Roy and Jacobson, 2004; Wittenmayer et al., 2004; Ding et al., 2006; Wu et al., 2006; Zou et al., 2007, 2009, 2010; Bae et al., 2009, 2010; Das et al., 2009; Yao et al., 2014; Diamond et al., 2015). Here, PFN1 is linked to cancer.