Moreover, all the mRNA expression levels of the angiogenic indicators Endoglin (Figure 7A) and Vegfa (Figure 7B), along with those of tumor marker carcinoembryonic antigen (CEACAM5) (Figure 7C) and green fluorescent protein (GFP) (Figure 7D), in the lung tissues of mice showed significant downregulation in the metformin and pemetrexed combination treatment group. The gene discussed is CEACAM5; the disease is neoplasm.