Detailed molecular pathways are yet to be established, but Ulk4 hypomorph mice displayed dysregulated inhibitory circuits (Liu et al., 2018a) and reduced white matter integrity (Liu et al., 2018b), the two most frequent phenotypes that predispose mental disorders and neurodevelopmental diseases (Lewis et al., 2005; Peters and Karlsgodt, 2015). Here, ULK4 is linked to mental disorder.