PARP1 and cancer: Poly(ADP-ribose) polymerase 1 (PARP1), the founding member of the PARP family, plays a crucial role in cancer biology, including chromatin remodeling, replication, transcription, and most importantly, DNA repair and genome maintenance (Ray Chaudhuri and Nussenzweig, 2017; Hanzlikova and Caldecott, 2019; Kim et al., 2020).