TP53 and neoplasm: By binding with p53, 53BP1 directly regulates the stability of p53 and affects the expression of p53 target genes, and it has been reported to regulate tumor cell behaviors in a variety of malignancies such as esophageal, colorectal, and breast cancers (Misteli and Soutoglou, 2009; Bi et al., 2015; Mirza-Aghazadeh-Attari et al., 2019; Yang et al., 2019; Schochter et al., 2020).