Mutation of SPOP and the resulting dysregulation of ubiquitin-proteasome pathways play an important role in the pathogenesis and progression of endometrial and prostate cancers, whereas its overexpression and mislocalization are correlated with kidney cancer (Li G. et al., 2014; Geng et al., 2017; Cuneo and Mittag, 2019; Wang Z. et al., 2020). This evidence concerns the gene SPOP and Familial prostate cancer.