BIRC3 and Familial prostate cancer: In prostate cancer cells and xenotransplantation models, apigenin decreases expression of apoptotic protein inhibitors such as XIAP, survivin, c-IAP1, and c-IAP2, inhibits HDAC1, upregulates acetylation of Ku70, destroys the Ku70-Bax interaction, and mediates apoptosis of prostate cancer cells by separating Bax and Ku70 (143).