The mechanism underlying the regulation of cancer cells is to promote expression of miR-146a, activate caspase-3 and Bax, and induce apoptosis through a mitochondrial-dependent pathway in human breast cancer cell lines MCF-7 and MDA-MB-231 to inhibit proliferation of tumor cells, inhibit expression of EGFR, and reduce invasiveness of tumor cells (129). The gene discussed is CASP3; the disease is neoplasm.