BCL2 and Miyoshi myopathy: Interestingly, a recent study showed that a long non-coding RNA LINCOO461 that acts as a decoy for miR-15a and miR-16 tumor suppressors was transferred to MM cells via MSC-derived EVs, resulting in inhibition of both miRNAs and upregulation of their target anti-apoptotic gene BCL2. As a result, EVs enriched in LINCOO461 inhibited apoptosis of MM cells and induced their proliferation (39).