For example, our and other groups have demonstrated that mitochondrial calcium uniporter (MCU), a key mediator of mitochondrial Ca2+ uptake, is upregulated in several cancer cell types, including CRC (6), breast cancer (7), hepatocellular carcinoma (HCC) (8) and glioblastoma (GBM) (9). The gene discussed is MCU; the disease is hepatocellular carcinoma.