In recent years, EGR1 was proven to directly or indirectly upregulate multiple tumor suppressors, such as PTEN, TP53, fibronectin, BCL-2 and TGFb1 (40, 41), and was expressed at low levels in a variety of cancers, such as colon cancer (42) and oophoroma (43). This evidence concerns the gene EGR1 and cancer.