The DEIRGs were enriched in 12 significant KEGG pathways: cytokine-cytokine receptor interaction (Figure 8A), TGF-beta signaling pathway (Figure 8B), ErbB signaling pathway (Figure 8C), neuroactive ligand-receptor interaction, neuroactive ligand-receptor interaction, melanoma, hematopoietic cell lineage, Jak-STAT signaling pathway, pathways in cancer, calcium signaling pathway, regulation of actin cytoskeleton, MAPK signaling pathway, and chemokine signaling pathway (Supplementary Table 15). The gene discussed is SOAT1; the disease is melanoma.