Clinical characteristics showed that the 1st L group had a lower prothrombin time (PT) (median (%): 83 vs. 90, p < 0.01), larger tumor size (median: 25 vs. 24 mm, p < 0.05), and heavier resection weight (median: 184 vs. 137 g, p < 0.05) than did the 2 nd M group. Here, F2 is linked to neoplasm.