Importantly, the abovementioned finding for the first time indicated that BMSC-derived exosomes alleviate LPS-induced ALI by reconstructing the miR-384-5p/Beclin-1 pathway, and exosomal miR-384-5p may be one of the protective factors to prevent alveolar macrophages from autophagy stress. Here, BECN1 is linked to acute respiratory distress syndrome.