Sam68 is a binding partner for CBP and represses expression of the Wnt target gene cyclin D1 41,42, and is overexpressed in breast and colon cancer cell lines that have cancer stem cell (CSC) properties, but not in non-CSC lines (e.g., Sam68 expression is higher in the CSC-like HT29 CRC cell line compared to the non-CSC-like SW480 line) 42. The gene discussed is KHDRBS1; the disease is colorectal carcinoma.