However, HNF1A is also reported to down-regulate the cell cycle and anti-apoptotic genes, and up-regulate the expression of apoptotic genes 8, inhibits to induce the resistance of pancreatic cancer cells to gemcitabine by targeting ABCB1 9, and regulates the proliferation activity of pancreatic cancer cells by increasing the PTEN/AKT signaling pathway 10. This evidence concerns the gene ABCB1 and familial pancreatic carcinoma.