In the current study, we assessed PSMD7 expression and its prognostic significance in NSCLC and observed that the expression of cell cycle proteins cyclin D1, CDK4, CDK1, and Cdc25c was markedly reduced in PSMD7-knockdown cells, suggesting that PSMD7 regulates gene transcription directly or indirectly. This evidence concerns the gene CDK4 and non-small cell lung carcinoma.