Lnc-SGK1 induced by Helicobacter pylori infection and high salt diet suggests a possibility of promoting Th2 and Th17 differentiation in human gastric cancer (GC) by SGK1/Jun B signaling 78 and lnc-sox5 was found to promote the expression of indoleamine 2,3-dioxygenase 1 (IDO1) to modulate the infiltration and cytotoxicity of CD3+CD8+ T cells in colorectal cancer (CRC) 79. The gene discussed is SOX5; the disease is gastric cancer.