Additionally, according to Liu Qian et al's research, lncRNA GAS5 upregulates adenovirus E4 binding protein 4 (E4BP4) which targets CD40L to inhibit activation of CD4+ T cell by inhibiting miR-92a-3p in systemic lupus erythematosus (SLE) 32. This evidence concerns the gene CD40LG and systemic lupus erythematosus.