CD274 and familial pancreatic carcinoma: For example, PD-L1 is upregulated in pancreatic cancer (PC) by lncRNA LINC00473 as a sponge of microRNA-195-5p 73 and lncRNA HOTTIP promotes IL-6 transcription by regulating transcription factor c-jun to activate the STAT3/PD-L1 pathway in neutrophils in ovarian cancer (OC) 74.