For instance, linc-POU3F3 activates TGF- β signal pathway to increase Treg distribution and thereby promote gastric cancer (GC) cell proliferation 80 and the transcription factor FOXC1 mediates LINC00301 increases Treg through targeting TGF-β in non-small cell lung cancer (NSCLC) is verified by Cheng-Cao Sun et al. 81. This evidence concerns the gene FOXC1 and non-small cell lung carcinoma.