The clinical data of the 87 CRC patients with high IDH1 expression tumors and 38 patients with low IDH1 expression tumors showed that high IDH1 expression was associated with a high-stage tumor (p < 0.001), distant metastasis (p = 0.006) and lymph node metastasis (p = 0.002, Table 1). Here, IDH1 is linked to neoplasm.